Drug Pipeline
Approved Treatments for Osteoporosis and What’s in the Pipeline
Along with the release of revised guidelines, several pharmacological therapies have become available or are under investigation to help improve outcomes in patients with osteoporosis. More »
Update on Coverage Mandates for Patients With Autism
The treatment of patients with autism spectrum disorders (ASDs) and their various complications has become one of the most discussed and demanded insurance coverage mandates in multiple states. Insurance mandates are being heavily pushed by advocacy groups, especially Autism Speaks, with good success. More »
Evidence-Based Perspective on Metabolic Syndrome and Use of Antipsychotics
Schizophrenia, a devastating mental illness that affects nearly 2.2 million Americans, is associated with high rates of morbidity and mortality.1 Persons with schizophrenia have a 20% shorter life expectancy than the general population.1,2 Furthermore, among persons with schizophrenia, there is an increased prevalence of metabolic syndrome characterized by a constellation of risk factors, including insulin resistance, abdominal obesity, dyslipidemia, hyperglycemia, and hypertension,3 More »
Psychiatric Symptoms Associated With Parkinson Disease
Parkinson disease (PD) is associated with a number of nonmotor symptoms, including depression, drug-induced psychosis and impulse control disorders, cognitive impairment, anxiety, and sleep disturbances. More »
Hyperparathyroidism Resulting From Lithium Treatment Remains Underrecognized
Until recently, I never paid much attention to the possibility that abnormalities of the parathyroid glands could be relevant to patients in my practice. But I decided to learn more about this issue when one of my patients with bipolar disorder who had been treated with lithium told me that she had been given a diagnosis of a parathyroid adenoma after her primary care physician noted hypercalcemia on routine testing. More »
US Spending Is Frozen on HIV Programs in Africa
The US decision to freeze spending on HIV programs in several African countries has caused concern that some of the progress made in the global AIDS epidemic will be reversed. More »
Rising Rates of Disability Among Older Adults
A recent study has shown that rates of disability may be rising among noninstitutionalized adults 65 years and older in the United States.1 “People are living longer, but many are also living sicker,” said Amani Nuru-Jeter, PhD, MPH, assistant professor of community health and human development at the University of California Berkeley School of Public Health, and coauthor of the study. More »
2009 H1N1 Influenza: Antiviral Use for Prevention and Treatment
This discussion reviews the currently available antivirals and recommendations for their use in influenza prophylaxis and treatment. Because our understanding of 2009 H1N1 influenza is still evolving, some off-label use of medications is discussed and noted. Information on 2009 H1N1 is updated frequently, andreaders are encouraged to monitor advisories from federal, state, and local health agencies for up-to-date information. (Drug Benefit Trends. 2010;22:10-14) More »
Why Physicians Do Not Follow Some Guidelines and Algorithms
Dozens of guidelines and algorithms are available from a range of authoritative sources to guide selection of psychopharmacology. More »
Insomnia: Recent Advances in Pharmacological Management
The medications currently approved for the treatment of insomnia include 9 benzodiazepine receptor agonist (BZRA) hypnotics and the selective melatonin receptor agonist ramelteon. More »
FDA Eases Rules on Access to Experimental Drugs
Under new FDA rules going into effect this month, more patients will be able to access experimental drugs without taking part in clinical trials. The new rules are meant to clarify a formal process in place since 1987 More »
The Assessment and Treatment of Drug-Resistant Tuberculosis
The development of drug-resistant strains of Mycobacterium tuberculosis has increased morbidity and mortality associated with tuberculosis (TB) and has greatly increased the costs of care for patients with this disease. More »
Antimicrobial Resistance Update: Klebsiella pneumoniae Carbapenemases
The rapid spread of Klebsiella pneumoniae carbapenemases (KPCs) is limiting the effectiveness of carbapenems in the treatment of multidrug-resistant infections. The resistance genes found in KPCs have been identified in other organisms as well and have properties that have raised concerns regarding their transmissibility and epidemic potential. More »
Evolution of a Medication Therapy Management Program
Since the 2006 launch of the Medicare Part D prescription drug benefit, the Centers for Medicare & Medicaid Services (CMS) has required all Part D sponsors, including Health Net, to offer free medication therapy management program (MTMP) services to members at high risk for drug-related problems. More »
Rheumatologists Embrace Biologics Despite Coverage Limits
As the number of biologic agents for rheumatoid arthritis (RA)—and rheumatologists’ use of these agents for RA and other rheumatological diseases—grows, getting coverage for RA treatment is taking an increasing investment of physicians’ staff time. However, the majority of respondents to a recent survey say it is an investment in patient care that is worth making. More »
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Additional Resources
www.nature.com - 12/6/11
of Genzyme&x27; s drug pipeline. ... With sales of around x00024; 130 billion since the drug&x27; s launch in 1997, Lipitor was the world&x27; s top-grossing medicine of all time.
www.ama-assn.org - 8/10/11
The fraction of substances receiving USANs that were biologics or polymers has remained relatively constant.Worldwide sales of single-enantiomer drugs were estimated to have grown at a rate of >13 percent in 2000, to $147.2 billion, accounting for 40 percent and 36 percent of all drug sales in 2000 and 2001.21 Drugs approved by the FDA during 1998-2001 were classified as follows: 52 percent achiral, 30 percent single enantiomers/diastereomers with several chiral centers, 7 percent single enantiomers with
www.hematology.org - 5/10/11
On December 7, 2010, the National Institutes of Health (NIH) Scientific Management Review Board (SMRB) approved a recommendation to create a new center the National Center for Advancing Translational Science (NCATS) at the NIH focused on translational medicine and therapeutics. This decision follows the Obama Administrations growing concern with the slowing rate of new drug production by the pharmaceutical industry.
dbt.consultantlive.com - 6/7/10
Along with the release of revised guidelines, several pharmacological therapies have become available or are under investigation to help improve outcomes in patients with osteoporosis.
genomemedicine.com - 3/4/11
The gut microbiome is the term given to describe the vast collection of symbiotic microorganisms in the human gastrointestinal system and their collective interacting genomes. Recent studies have suggested that the gut microbiome performs numerous important biochemical functions for the host, and disorders of the microbiome are associated with many and diverse human disease processes. Systems biology approaches based on next generation 'omics' technologies are now able to describe the gut microbiome at a

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